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Updated: May 11, 2026

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神经纤维光链作为遗传ATTR氨基粉症的生物标志物 - 神经纤维光链与神经传导研究之间的相关性

Masateru Tajiri1, Mitsuto Sato1, Minori Kodaira1

  • 1Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.

Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis
|October 8, 2024
PubMed
概括

神经纤维光链 (NfL) 显示在遗传ATTR粉样化症中与神经传导研究 (NCS) 参数有很强的相关性. 与NCS相比,NfL是检测神经损伤和治疗反应的更敏感的生物标志物.

关键词:
遗传性ATTR氨基粉症是一种遗传性ATTR氨基粉症.生物标志物生物标志物复合肌肉动作潜力是一种动作潜力.神经传导研究 神经传导研究神经纤维光链的光链.帕蒂斯拉里安 (Patisiran) 是一个转二烯是什么意思

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...