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相关概念视频

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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扩散加权MRI的QIBA概况:明显扩散系数作为定量成像生物标志物.

Michael A Boss1, Dariya Malyarenko1, Savannah Partridge1

  • 1From the Center for Research and Innovation, American College of Radiology, 50 S 16th St, Philadelphia, PA 19102 (M.A.B.); Department of Radiology, University of Michigan, Ann Arbor, Mich (D.M., T.L.C.); Department of Radiology, University of Washington, Seattle, Wash (S.P.); Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio (N.O.); Departments of Medical Physics and Radiology, Memorial Sloan Kettering Cancer Center, New York, NY (A.S.D.); The Institute of Cancer Research, London, UK (J.M.W., N.M.d.S.); The Royal Marsden NHS Foundation Trust, London, UK (J.M.W., N.M.d.S.); Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Tex (C.D.F.); CaliberMRI, Boulder, Colo (K.M.); Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (V.M.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, Calif (M.O., L.J.W.); Aim Medical Imaging, Vancouver, Canada (R.A.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (T.A.); and Department of Radiology, Weill Cornell Medical College, New York, NY (D.J.M.).

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概括

像表面扩散系数 (ADC) 这样的定量成像生物标志物对于监测疾病至关重要. 新的指导方针建立了ADC大脑,肝脏,前列腺和乳腺病变变化的基准,确保可靠的治疗反应评估.

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科学领域:

  • 医疗成像医学成像
  • 生物标志物开发 生物标志物开发
  • 量化MRI是指数量化的MRI.

背景情况:

  • 表面扩散系数 (ADC) 量化水的流动性,反映了疾病和治疗中的组织微观结构变化.
  • 标准化的ADC测量变异对于临床实施和可靠的生物标志物使用至关重要.

研究的目的:

  • 对平均损伤ADC变化的计量学基准进行审查和更新,并考虑测量方差.
  • 以95%的保证率,为各种器官的真实ADC变化提出具体的百分比值.

主要方法:

  • 对ADC可重复性和性能要求的现有文献的审查.
  • 基于最近的研究,制定了计量学基准标准的提议更新.
  • 分析已建立的ADC配置文件阶段和实施工作流程.

主要成果:

  • 关于真实平均ADC变化的建议基准:8% (大脑),27% (肝脏),27% (前列腺) 和15% (乳腺).
  • 这些值在检测真实变化时提供95%的可靠性,考虑到测量方差.

结论:

  • 量化成像生物标志物联盟 (QIBA) 的ADC概况指南促进了ADC的临床应用.
  • 标准化的ADC测量可确保对纵向变化和治疗反应进行可重复的评估.