针对神经炎症的药物供应以治疗大脑疾病
Juntao Wang1, Ruiqin Jia2, Wubo Wan3
1School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, 437100, China.
Bioconjugate chemistry
|October 8, 2024
概括
针对大脑炎症需要克服血脑屏障 (BBB). 本综述探讨了阿尔茨海默病和中风中神经炎症的BBB透药物输送系统的最新进展.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 神经炎症是许多大脑疾病的关键特征,呈现出潜在的治疗目标.
- 目前的抗炎药物难以穿越血脑屏障 (BBB),这限制了它们在治疗大脑疾病方面的有效性.
- 阿尔茨海默病和缺血性中风是全球死亡和残疾的主要原因,通常涉及神经炎症.
研究的目的:
- 审查针对大脑炎症的药物输送策略的最近 (过去五年) 的进展.
- 专注于能够跨越血脑屏障 (BBB) 的策略.
- 检查阿尔茨海默病和缺血性中风模型中的应用.
主要方法:
- 在过去五年内发表的研究的文献综述.
- 专注于为BBB透而设计的药物输送系统.
- 对阿尔茨海默病和缺血性中风应用的策略分析.
主要成果:
- 几种新型药物输送系统显示,BBB透和向神经炎症具有前途.
- 进步包括基于纳米技术的载体,聚焦超声波和受体介导的细胞转移.
- 这些策略旨在改善大脑病理部位的治疗度.
结论:
- 有效的BBB透药物输送对于治疗神经炎症性脑疾病至关重要.
- 最近的创新为管理阿尔茨海默病和中风等疾病提供了新的希望.
- 需要进一步的研究来应对挑战,并优化这些交付系统用于临床使用.
相关概念视频
Drug Delivery: Parenteral Route
440
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
440
The Blood-brain Barrier
47.0K
Overview
47.0K
Drug Delivery: Miscellaneous Routes
329
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
329
Brain Imaging
216
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
216


