唾液代谢学:口腔疾病中的概念和应用
Pedro Nunes Garcia1, Milena Monteiro de Souza2, Mario Augusto Izidoro3
1International Research Center, Centro Internacional de Pesquisa, A.C. Camargo Cancer Center, Rua Taguá, 440 - Primeiro andar, São Paulo, 01508-010, Brazil.
Clinical oral investigations
|October 8, 2024
概括
唾液代谢学为口腔疾病提供了强大的诊断和预后见解. 本综述详细介绍了方法和发现,强调了个性化治疗策略的关键代谢物.
科学领域:
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
- 口腔医学是指口腔医学.
背景情况:
- 代谢学分析小分子 (代谢物) 以了解生物过程.
- 唾液是一种易于使用的生物流体,用于非侵入性诊断应用.
- 口腔疾病呈现出复杂的生化变化,可以通过代谢分析进行检测.
研究的目的:
- 审查代谢学方法的方法.
- 探索唾液在口腔疾病的诊断,预后和预测策略中的实用性.
- 为了总结口腔健康的唾液代谢学当前的应用和发现.
主要方法:
- 在PubMed上进行系统的文献搜索,重点是"唾液代谢学"和"口腔疾病".
- 包括评估代谢学技术的原始研究和评论.
- 研究设计,分析方法和代谢物确定工具的描述性分析.
主要成果:
- 代谢分析整合了分析仪器和生物信息学.
- 审查了25项研究,其中17项采用非向和8项向代谢学.
- 在口腔疾病中发现的关键代谢物包括甘氨酸,氨酸,氨酸和乳酸.
- 通常研究的口腔疾病是牙周病,口腔状细胞癌和Sjögren综合征.
结论:
- 代谢学是瘤诊断,分类 (包括唾液腺瘤) 和个性化治疗规划的强大工具.
- 它能够准确地进行预后分类,并增强对基因功能和生物体生化状态的理解.
- 唾液代谢学对推进口腔疾病管理和个性化医学具有重大前景.
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