患有腺病毒的儿童的细菌性炎症反应导致不适当的抗生素使用:一个多中心队列研究
Cristina Moracas1,2, Marco Poeta3,4, Francesca Grieco5
1Pediatric Infectious Disease Unit, Department of Maternal and Child health, University Hospital "Federico II", Naples, 80131, Italy.
Infection
|October 8, 2024
概括
儿童感染人类腺病毒 (HAdV) 会导致更强烈的炎症反应,但呼吸系统症状不如其他病毒严重. 早期识别HAdV可以防止不必要的抗生素使用.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 人类腺病毒 (HAdV) 是儿童常见的病毒病原体.
- 与其他呼吸道病毒相比,了解HAdV的临床谱对于适当的管理至关重要.
- 在儿科呼吸道感染中区分病毒病因可能具有挑战性.
研究的目的:
- 为了比较人类腺病毒 (HAdV) 感染的临床严重程度与儿童队列中的其他病毒性疾病.
- 评估小儿病患者HAdV感染的呈现,治疗和结果.
- 确定影响HAdV儿童临床表现和治疗的因素.
主要方法:
- 在2023年1月至12月期间,在意大利住院患有呼吸道症状的儿童中进行了一项回顾性多中心队列研究.
- 包括患有呼吸道症状的HAdV感染的儿童;孤立的胃肠道感染或细菌共感染的儿童被排除在外.
- 分析了包括症状,实验室标志物和治疗在内的临床数据,并在HAdV感染者和其他病毒群体之间进行了比较.
主要成果:
- 共有171名儿童被录取:98名患有HAdV,73名患有其他病毒.
- 受HAdV感染的儿童的C-反应蛋白水平较高 (50.8比16.5毫克/升),发烧持续时间较长 (4.9比3.4天).
- 尽管呼吸困扰和低氧化症的频率较低,但HAdV病例更有可能接受抗生素 (77.6%对27.4%).
结论:
- 儿童的HAdV感染与更明显的炎症反应和持续发烧有关,尽管呼吸道症状不那么严重.
- 强烈的炎症标志物和发烧通常会导致在病毒诊断之前经验性过度使用抗生素.
- 早期和准确地识别HAdV是指导治疗,优化管理和减少不必要的抗生素处方至关重要的.
更多相关视频
08:33Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
12.9K
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
10.3K
相关概念视频
00:57Antibiotic Selection
52.4K
Overview
52.4K
01:30Acute Pharyngitis
498
Introduction
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
498
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
111
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
111