血生物标志物对心力衰竭预测,管理和预后的潜力:一个多组学观点

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Erhou Zou¹, Xinjie Xu¹, Liang Chen²

¹State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Heart failure reviews

|October 8, 2024

概括

本综述强调了omics方法,用于发现心力衰竭 (HF) 中的血生物标志物. 未来的研究应该整合多体经济学,并在大型队列中验证发现,以更好地管理高频率.

科学领域:

生物化学生化学
基因组学就是基因组学.
蛋白质组学是指蛋白质组学.
代谢学代谢学代谢学

背景情况:

心力衰竭 (HF) 对全球健康造成重大负担,需要改善血生物标志物以有效治疗患者.
目前的研究表明,在DNA片段,非编码RNA,蛋白质和通过多组学研究识别的代谢物中存在潜在的高频生物标志物.
在综合性审查中存在一个差距,重点是针对高频率的OMIC驱动的血生物标志物研究.

研究的目的:

审查各种奥米克学方法在识别高频率血生物标志物的应用.
涵盖HF风险评估,诊断,分类,管理和预后的生物标志物.
检查心脏移植排斥中的无细胞DNA和LVAD治疗中的血生物标志物的OMIC.

主要方法:

系统审查与心力衰竭等离子体生物标志物相关的多组学研究.
从DNA片段,非编码RNA,蛋白质和代谢物中分析omics数据.
包括关于先进的HF治疗方法的研究,如心脏移植和LVAD.

主要成果:

奥米克斯方法为心力衰竭的各个方面提供了广泛的潜在血生物标志物.
无细胞DNA显示为心脏移植排斥的生物标志物具有前途.
欧米克斯研究正在探索接受LVAD治疗的患者的血生物标志物.

结论:

综合的多组学方法对于强大的高频生物标志物发现至关重要.
扩大样本大小和在大群体中验证生物标志物对于临床转化至关重要.
未来的研究应该专注于全面的,经过验证的基于奥米克的血生物标志物,以改善HF护理.

关键词:

生物标志物生物标志物心脏衰竭是因为心脏衰竭.代谢过程中的代谢.蛋白质组学是指蛋白质组学.文字转录学 (Transcriptomics) 是一个学科.

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