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加勒比地区乳腺癌妇女的生殖风险因素模式,跨越了4代的乳腺癌.

Alex P Sanchez-Covarrubias1,2,3, Maurice J Chery2,3,4, Priscilla Barreto-Coehlo2,5

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此摘要是机器生成的。

年轻的加勒比地区妇女被诊断患有乳腺癌 (BC) 正经历更早的初潮和更少的怀孕. 这些生殖模式的变化凸显了这一群体中不断演变的BC风险因素.

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科学领域:

  • 在瘤学瘤学.
  • 流行病学 流行病学
  • 生殖健康 生殖健康

背景情况:

  • 乳腺癌 (BC) 是加勒比地区妇女的重大健康问题.
  • 众所周知,生殖模式会影响BC发病率和诊断时的年龄.
  • 加勒比地区妇女的生殖模式未得到充分研究,需要集中研究.

研究的目的:

  • 研究加勒比地区出生的女性生殖模式的时间趋势.
  • 在不同出生队伍中检查乳腺癌诊断时的年龄变化.

主要方法:

  • 进行了一项横截面的观察性研究,即加勒比妇女癌症研究.
  • 从2010年至2018年期间被诊断患有侵袭性BC或卵巢癌的加勒比国家出生的妇女收集数据.
  • 参与者被分为四个出生队伍 (1950年之前,1950年至1959年,1960年至1969年,1970年+).

主要成果:

  • 较年轻的出生队伍显示,12岁或更年轻的初潮女性比例较高,没有怀孕,和无双.
  • 早些时候的BC诊断与12岁或更年轻的初潮和无双性有关.
  • 延迟第一次怀孕增加了雌激素受体阳性瘤的可能性 (OR,1.04;95% CI,1.01-1.08).

结论:

  • 转变的生殖模式,包括更早的初潮和更少的怀孕,在加勒比地区妇女与BC.的连续出生队伍中观察到.
  • 这些变化与在BC诊断时的年轻年龄和特定瘤特征相关.
  • 针对不断变化的BC风险因素的干预措施对这一群体至关重要.