加勒比地区乳腺癌妇女的生殖风险因素模式,跨越了4代的乳腺癌
Alex P Sanchez-Covarrubias1,2,3, Maurice J Chery2,3,4, Priscilla Barreto-Coehlo2,5
1Cancer Biology Graduate Program, Miller School of Medicine, University of Miami, Miami, Florida.
JAMA network open
|October 8, 2024
概括
年轻的加勒比地区妇女被诊断患有乳腺癌 (BC) 正经历更早的初潮和更少的怀孕. 这些生殖模式的变化凸显了这一群体中不断演变的BC风险因素.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生殖健康 生殖健康
背景情况:
- 乳腺癌 (BC) 是加勒比地区妇女的重大健康问题.
- 众所周知,生殖模式会影响BC发病率和诊断时的年龄.
- 加勒比地区妇女的生殖模式未得到充分研究,需要集中研究.
研究的目的:
- 研究加勒比地区出生的女性生殖模式的时间趋势.
- 在不同出生队伍中检查乳腺癌诊断时的年龄变化.
主要方法:
- 进行了一项横截面的观察性研究,即加勒比妇女癌症研究.
- 从2010年至2018年期间被诊断患有侵袭性BC或卵巢癌的加勒比国家出生的妇女收集数据.
- 参与者被分为四个出生队伍 (1950年之前,1950年至1959年,1960年至1969年,1970年+).
主要成果:
- 较年轻的出生队伍显示,12岁或更年轻的初潮女性比例较高,没有怀孕,和无双.
- 早些时候的BC诊断与12岁或更年轻的初潮和无双性有关.
- 延迟第一次怀孕增加了雌激素受体阳性瘤的可能性 (OR,1.04;95% CI,1.01-1.08).
结论:
- 转变的生殖模式,包括更早的初潮和更少的怀孕,在加勒比地区妇女与BC.的连续出生队伍中观察到.
- 这些变化与在BC诊断时的年轻年龄和特定瘤特征相关.
- 针对不断变化的BC风险因素的干预措施对这一群体至关重要.
更多相关视频
相关概念视频
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Disorders of the Female Reproductive System
333
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
333
Probability Laws
40.5K
Overview
40.5K
Pedigree Analysis
84.0K
Overview
84.0K
Cancers Originate from Somatic Mutations in a Single Cell
11.8K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.8K
Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K


