在美国男性中,同类半氨酸对勃起功能障碍风险的年龄依赖性影响 男:一个NHANES分析分析
Xuewen Diao1,2, Chenming Zhang3, Zulong Wang1
1Department of Andrology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan, China.
American journal of men's health
|October 8, 2024
概括
同型半氨酸 (HCY) 水平与勃起功能障碍 (ED) 风险有关,特别是在50岁及以上的男性中. 管理HCY可能有助于预防和治疗这个人口中的ED.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 勃起功能障碍 (ED) 显著影响男性的生活质量和心理健康.
- 以前的研究表明,同类氨酸 (HCY) 水平与ED风险之间存在潜在联系,但研究有限.
- 混因素和小样本规模在历史上阻碍了最终的结论.
研究的目的:
- 评估美国成年男性的同类氨酸 (HCY) 水平和勃起功能障碍 (ED) 风险之间的关联.
- 调查与年龄的潜在非线性关系和相互作用.
- 为ED提供有针对性的预防策略提供证据.
主要方法:
- 使用了来自国家健康和营养检查调查 (NHANES) (2001-2004) 的数据.
- 使用加权通用线性模型进行主要效应分析.
- 应用受限立方线 (RCS) 来探索与年龄的非线性关联和相互作用分析.
主要成果:
- 在对共变量进行调整后,HCY和ED之间的总体关联在统计学上并不显著.
- 相互作用分析显示,HCY-ED关系随着年龄的增长而加强.
- 在50岁及以上的男性中,高HCY水平 (特别是>9.22μmol/L) 与ED风险增加有显著的相关性.
结论:
- 同型氨酸 (HCY) 在勃起功能障碍 (ED) 风险中起着重要作用,特别是在老年男性中.
- 控制HCY水平可能是预防和治疗中老年和老年人ED的可行策略.
- 这些发现支持开发用于ED预防的HCY向干预措施.
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