在癌症治疗中用于合理设计gemcitabine配方的金属复合物
Federica Carnamucio1, Claudia Foti2, Massimiliano Cordaro2
1Department of Pharmaceutics and Center for Pharmaceutical Engineering and Sciences - School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23284, United States.
ACS applied materials & interfaces
|October 8, 2024
概括
这项研究引入了金属-金胺复合物,以改善化疗的治疗. 金属-宝石胺复合物增强了宝石胺.
科学领域:
- 纳米医学和药物输送
- 计算化学计算化学
- 材料科学 材料科学 材料科学
背景情况:
- 吉米西塔 (一种化疗药物) 的稳定性和药理动力学不佳,限制了它的有效性.
- 目前的gemcitabine纳米配方在药物加载和控制释放方面遇到了困难.
- 需要新的策略来改善用于癌症治疗的杰米西塔输送.
研究的目的:
- 开发一种新的策略,用于使用金属复合的gemcitabine纳米配方.
- 为了研究凝和生物相关金属子 (Mn2+,Zn2+,Ca2+) 之间的相互作用.
- 优化金属-金胺复合的条件,以改善纳米配方的开发.
主要方法:
- 在不同的条件下 (温度,pH,摩尔比率) 分析gemcitabine-metal相互作用的特异化研究.
- 密度函数理论 (DFT) 计算,以了解原子层面的相互作用机制.
- 旋转极化初始分子动力学模拟,提供对相互作用的原子洞察力.
主要成果:
- 用Mn2+,Zn2+和Ca2+探索金属-金酸丁复合.
- 确定了金属-宝石胺相互作用的优化条件.
- 在体外,Mn2+-gemcitabine物种维持了gemcitabine的生物活性.
结论:
- 金属-宝石胺复合是一种有前途的策略,用于开发先进的纳米配方.
- 这种方法可以带来对gemcitabine纳米配方的质量提高的目标产品配置文件.
- 这些发现表明,癌症治疗疗效,药理动力学和毒性降低的潜力.
更多相关视频
08:57Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
Published on: October 5, 2017
10.9K
09:56Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
14.9K
相关概念视频
01:19Complexation Equilibria: The Chelate Effect
470
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
470
01:22EDTA: Chemistry and Properties
1.8K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
1.8K
00:43Complexometric Titration: Ligands
919
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
919
01:09Complexation Equilibria: Factors Influencing Stability of Complexes
346
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
346
02:51Metal-Ligand Bonds
20.6K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
20.6K
01:15Drugs that Stabilize Microtubules
2.0K
Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
2.0K