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多民族队列研究中的空气污染和乳腺癌发病率

Anna H Wu¹, Jun Wu², Chiuchen Tseng¹

¹Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

|October 8, 2024

概括

暴露于细颗粒物 (PM_2.5) 与乳腺癌风险增加有关,特别是在多样化的群体中. 通过公共政策减少PM_2.5对于预防乳腺癌至关重要.

科学领域:

环境流行病学环境流行病学
公共卫生公共卫生
在瘤学瘤学.

背景情况:

最近的研究表明,细颗粒物 (PM_2.5) 暴露与乳腺癌风险增加之间存在联系.
然而,来自不同种族和民族的人口的证据有限,需要进一步调查.

研究的目的:

为了检查长期PM_2.5暴露和入侵性乳腺癌风险在一个大,多民族队列之间的关联.
调查不同种族/族群和乳腺癌亚型之间这种关联的潜在异质性.

主要方法:

该研究分析了多民族队列研究 (MEC) 中58358名女性参与者的数据,平均随访时间为19.3年.
考克斯比例危险回归被用来评估时间变化的PM_2.5暴露和乳腺癌发病率之间的关系,调整为混因素.
根据种族,种族,激素受体状态和乳腺癌家族病史进行了子组分析.

主要成果:

在更高的PM_2.5暴露和乳腺癌发病率增加 (HR每10μg/m³,1.28) 之间发现了统计学上显著的关联.
在PM_2.5-乳腺癌关联中没有观察到跨种族,种族或激素受体状态的显著异质性.
一项将MEC数据与其他10个队列结合的元分析也表明,暴露于PM_2.5的乳腺癌风险增加 (HR每10μg/m^3,1.05).

结论:

这项大型多民族研究强烈支持PM_2.5作为乳腺癌的重要风险因素.
调查结果强调需要全民政策来减少PM_2.5暴露,作为乳腺癌预防策略的关键组成部分.
这些公共卫生干预措施是必不可少的,特别是考虑到全球乳腺癌发病率的上升以及未解释的部分病例.

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