印度人口中的人口参与和COVID-19临床特征的转变:从野生型SARS-CoV-2到印度人口中的三角洲变种:在基分析中
Ashutosh Kumar1, Adil Asghar1, Khursheed Raza2
1Department of Anatomy, All India Institute of Medical Sciences-Patna, Patna, India.
Interactive journal of medical research
|October 8, 2024
概括
德尔塔型的SARS-CoV-2导致了更多的年轻人和女性感染,疾病的平均年龄降低,死亡率增加,特别是在女性中. 接种疫苗后的感染也更频繁.
科学领域:
- 流行病学 流行病学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 这种SARS-CoV-2德尔塔变种 (B.1.617.2) 已成为一种高度令人担忧的菌株.
- 与野生型 (WT) 菌株 (B.1) 相比,存在关于三角洲变种的人口和临床影响的有限数据.
研究的目的:
- 调查COVID-19人口和临床特征随着SARS-CoV-2三角洲变种的出现而发生的变化.
- 将这些特征与野生型 (WT) 菌株 (B.1) 进行比较.
主要方法:
- 一项横截面研究分析了来自印度人口 (N=9500) 的病毒基因组序列元数据.
- 数据包括WT (N=3262) 和Delta (N=6238) 菌株的人口统计,疫苗接种和患者状况细节.
- 进行了统计分析来比较这两种菌株.
主要成果:
- 德尔塔变种在20岁以下的人群中感染比例较高 (P<.001),感染女性比例增加 (P<.001).
- 年轻人和女性 (与男性相比) 患有德尔塔变种的症状疾病和住院治疗率较高 (P<.001).
- 感染和住院的平均年龄随着三角洲变种的出现而下降,整体死亡率高出1.8倍,女性死亡率增加 (P<.001).
结论:
- "三角洲"变种显著增加了年轻人和妇女参与大流行的比例.
- 较低的平均发病年龄和较高的死亡率被观察到与三角洲变种.
- 经常出现疫苗接种后感染,引发了严重的流行病学问题.
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