一个随机的安慰剂控制的营养试验的逻辑和设计,包括一个公民科学方法
Marieke van de Put1, Maartje van den Belt2, Nicole de Wit2
1Amsterdam Institute for Life and Environment, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.
Nutrition research (New York, N.Y.)
|October 8, 2024
概括
食纤维和发酵食品可能会影响肠道微生物群. 这项研究在随机对照试验中使用了公民科学方法,证明了肠道健康研究的可行性和高度合规性.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 饮食干预措施,包括纤维和发酵食品,显示了调节肠道微生物群和改善健康的潜力.
- 目前关于食纤维和发酵食品对肠道微生物群的特定影响的证据有限.
- 公民科学 (CS) 方法可以增强健康研究中的参与和数据收集.
研究的目的:
- 研究高食纤维和高发酵食品饮食对肠道微生物群多样性和组成的影响.
- 评估将公民科学元素纳入肠道健康研究随机对照试验的可行性.
- 评估干预后饮食行为变化的可持续性.
主要方法:
- 一项为期21周的随机对照试验,涉及147名健康成年人.
- 干预措施包括高食纤维,高发酵食品或控制饮食,分别补充了西瓜根,发酵饮料或马尔托德克斯特林.
- 公民科学组件包括教育,定制饮食,远程数据收集,个性化反和参与者视频博客.
主要成果:
- 招聘成功,有1448个申请,表明参与者的兴趣很高.
- 观察到高符合率 (>90%) 饮食指南和研究产品.
- 该研究协议证明了将公民科学纳入随机对照试验的可行性.
结论:
- 公民科学元素可以显著帮助参与者招募和随机对照试验的合规性.
- 该研究方案为未来的肠道健康研究提供了一个可行的模型,其中包括公民科学.
- 需要进一步的研究来阐明食纤维和发酵食品对肠道微生物群的具体影响.
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