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在不同ACVIM阶段的骑士查尔斯国王西班牙犬中,左心房体积和功能

Paolo Savarino¹, Serena Crosara², Marco Poggi³

¹Department of Veterinary Sciences, University of Torino, Largo Braccini 2, Grugliasco, TO, Italy.

Research in veterinary science

|October 8, 2024

概括

左心房重塑在骑士查尔斯国王西班牙犬中显而易见,他们患有早期的退行性米特拉病. 在有症状的狗中,心房功能障碍是显而易见的,这凸显了评估左心房大小和功能的重要性.

科学领域:

兽医心脏病学兽医心脏病学
狗狗心脏回声学狗狗心脏回声学
中心门疾病的疾病.

背景情况:

准确评估左心房 (LA) 大小和功能对于评估狗中退行性米特拉病的严重程度至关重要.
骑士查尔斯国王西班牙犬 (CKCS) 容易患上中枢病,这使得它们成为心脏研究的关键品种.

研究的目的:

评估CKCS在不同ACVIM疾病阶段的左心房 (LA) 尺寸和功能.
评估线性和体积回声心脏指数的准确性,以检测CKCS中LA扩大.

主要方法:

一项多中心前性观察研究,涉及198家私人CCKCS.
为品种查和心脏评估进行了心声图检查.
线性和体积LA大小和功能指数在ACVIM疾病阶段之间进行了比较.

主要成果:

根据体重 (LADn) 和LA体积 (LAVmax,LAVmin,LAVP) 规范化的左心房前后直径在所有对对比中显著不同.
主动LA排空分数 (aLAEF) 最初在ACVIM B1阶段的狗中增加 (表明弗兰克-斯塔林机制),随后在症状 (ACVIM C/D) 的狗中减少.
在早期疾病阶段 (ACVIM B1 vs. A) 检测到LA重塑,在有症状的狗中明显出现心房功能障碍.

结论:

左心房重塑在CKCS中存在,即使在退行性米特拉病的早期ACVIM B1阶段.
在患有晚期疾病的有症状的狗中,心房功能障碍明显明显.
LADn和LAV测量是中关膜疾病影响的CKCS中LA变化的有价值指标.

关键词:

心脏扩大是因为心脏的扩大.狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗心声回声扫描 (Echocardiography) 是一种心声回声扫描.这是一个MMVDVD.

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