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对固体相微提取的生物分析和临床应用进行批判性审查

Sılanur Sevgen¹, Gökşin Kara¹, Aysegul Seyma Kir¹

¹Department of Chemistry, Middle East Technical University, Ankara 06800, Türkiye.

Journal of pharmaceutical and biomedical analysis

|October 8, 2024

概括

固相微提取 (SPME) 为分析生物系统提供了一种环保,与生物体相容的方法. 这种技术推进了药物分析,代谢学和临床研究,使生物系统能够更深入地了解.

科学领域:

分析化学分析化学
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

经典的样本准备方法与体内分析和环境影响作斗争.
固相微提取 (SPME) 为生物分析研究提供了一种多功能替代方案.
在环境友好性,体内适用性和在线分析方面,SPME提供了优势.

研究的目的:

在过去五年中审查SPME在生物分析中的应用.
审查SPME在药物分析,代谢学和临床研究方面的能力.
讨论未来生物分析研究的新型SPME阶段和仪器合策略.

主要方法:

在过去五年中发表的关于SPME在生物分析中的研究的文献综述.
评估SPME在药物分析,向和非向代谢学方面的表现.
评估SPME的体内,临床和单细胞采样应用.

主要成果:

SPME是生物系统在体内研究和代谢组分析的关键工具.
微型的SPME探头能够进行低侵入性采样,即使是从单个细胞.
将SPME与质谱直接合,简化了诊断和药物分析的工作流程.

结论:

SPME是生物分析中不可或缺的技术,为各种应用提供了先进的功能.
新的SPME开发和仪器合正在扩大其在生物研究中的实用性.
SPME促进了对生物系统,药物效应和疾病诊断的更深入的洞察.

关键词:

生物分析分析分析生物分析分析直接对MS进行分析.在生物体内采样采样代谢学代谢学代谢学药品制造业药品制造业药品制造业药品制造业固相微提取固相微提取方法

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