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Updated: Jun 11, 2025

Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells
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Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells

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对PRMT5抑制剂的药物化学见解

Zhihao Jiao1, Yongmi Huang1, Kexin Gong1

  • 1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, PR China.

Bioorganic chemistry
|October 8, 2024
PubMed
概括

蛋白质氨酸甲基转移酶5 (PRMT5) 对细胞过程至关重要,并与癌症有关. 本综述涵盖了PRMT5抑制剂,从早期查方法到新的PROTAC和合成致命方法,用于癌症治疗.

关键词:
癌症 癌症 癌症 癌症药物发现 药物发现蛋白质氨酸甲基转移酶5 (PRMT5) 的作用.结构与活动关系 (SARs)

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相关概念视频

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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