在绵羊体内肌肉内L-carvone的药理动力学
Robert J Brosnan1, Heather K Knych2, Alessia Cenani1
1Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA.
American journal of veterinary research
|October 8, 2024
概括
肌肉内注射的薄荷成分L-carvone在绵羊中显示出快速的吸收和缓慢的排泄. 需要进一步的配方来减少注射部位的炎症和亡.
科学领域:
- 药理学 药理学是指药理学的学科.
- 兽医医学 兽医医学 兽医医学
- 自然产品 自然产品
背景情况:
- L-carvone 是一种天然的止痛药,可以在薄荷中找到.
- 了解其药理动力学和作用对于潜在的治疗用途至关重要.
- 绵羊是研究牲畜药物行为的相关模型.
研究的目的:
- 在肌肉内注射后,随着时间的推移量化羊血和组织中的L-carvone度.
- 为了建模L-carvone在绵羊中的药理动力学概况.
- 评估L-carvone对全血细胞计数 (CBC) 和临床生物化学面板的影响.
主要方法:
- 对六只羊进行肌肉内注射L-carvone,剂量为71.6 mg/kg.
- 血和组织样本是在24小时内收集的.
- 使用HPLC-MS-MS测量L-carvone度,并使用非线性混合效应模型分析药物动力学数据.
主要成果:
- 血L-carvone的峰值度迅速达到 (9-15分钟),并且在0.28至1.93μg/mL之间.
- 消除半衰期在中央体中为33.7分钟,在外围体中为390.2分钟.
- 观察到中性粒细胞的轻微增加和肌激酶和酸氨基转移酶的显著升高,与注射部位肌髓缩有关.
结论:
- 肌肉内注射的L-carvone表现出快速吸收和缓慢排泄,24小时后组织度较低.
- 药物动力学特征表明它具有作为止痛药的潜力,但需要改进配方,以减轻注射部位反应,如炎症和亡.
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