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揭示ER压力,UPR和cGAS-STING通路之间的相互作用:对骨关节炎病原和治疗策略的影响

Li-Jen Soh1, Siam-Yee Lee1, Margaret M Roebuck2

  • 1Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia.

Life sciences
|October 8, 2024
PubMed
概括

骨关节炎涉及细胞应激,细胞内网膜 (ER) 应激,以及未折叠蛋白质反应 (UPR). 循环GMP-AMP合成酶 (cGAS) 刺激干扰素基因 (STING) 途径可能导致OA的炎症和软骨损失.

关键词:
细胞内膜网膜应激压力炎症 炎症是一种炎症.骨关节炎是一种骨关节炎.治疗策略 治疗策略不折叠的蛋白质反应反应在cGAS-STING信号轴上

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