增加了ABO血型抗原分泌表现型,具有O血型和年龄的增加
Jamil M Obaid1, Sultan A Saghir1, Amir M Al-Hroob1
1From the Department of Medical Laboratory Sciences (Obaid, Mohammed), Faculty of Medicine and Health Sciences; from the Department of Medical Microbiology (Obaid), Faculty of Science, Ibb University, from the Department of Medical Laboratories (Obaid, Melhi, Alhomamy, Al-Qodaimi), Faculty of Medical Sciences, International Malaysian University, Ibb, Yemen, and from the Department of Medical Analysis (Saghir, Al-Hroob), Princess Aisha Bint Al-Hussein College of Nursing and Health Sciences, Al-Hussein Bin Talal University, Ma'an, Jordan.
在也门,78.1%的人是ABH抗原分泌者,患病率因血型而异,随年龄增长而增加. 血型O显示出最高的分泌器频率,而AB显示出最低的.
科学领域:
- 免疫遗传学 免疫遗传学
- 人类遗传学 人类遗传学
- 人口遗传学 人口遗传学
背景情况:
- ABH分泌的表型是由分泌者 (SE) 基因决定的,它影响了体液中ABH抗原的存在.
- 了解ABH分泌和非分泌表型的患病率对于人口遗传学和疾病关联研究至关重要.
研究的目的:
- 在也门人口中确定ABH抗原分泌者和非分泌者的流行率.
- 为了调查潜在的因素,如血型和年龄,影响表达的分泌物表现型.
主要方法:
- 一项涉及215名健康的也门人的横截面研究.
- 血液样本使用标准血清学方法分析了ABH血型抗原.
- 唾液样本使用血液凝结抑制试验测试了ABH抗原分泌.
主要成果:
- 在也门队列中,ABH秘的总体患病率为78.1%.
- 秘体状况与血型O (95%的分泌者) 和AB (54%的分泌者) 显著相关.
- 增加的年龄与分泌基因 (SE) 的更高表达相关,而Rh阴性个体显示出更高的分泌率.
结论:
- 在也门Ibb省的ABH分泌物表型频率为78.1%.
- 血型O表现出最高的分泌器频率 (95%),而血型AB则是最低的 (54%).
- 秘表现型表达随着年龄的增长而增加,随后下降,并且在Rh阴性个体中更为普遍.
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