在甲状腺癌临床试验中,基于语言的排斥与种族和民族差异的关联
Likolani Arthurs1, Samuel Fredericks2, Younes Attlassy2
1Department of Surgery, New York University Grossman School of Medicine and NYU Langone Health, New York, NY.
Surgery
|October 8, 2024
概括
甲状腺癌的临床试验经常基于语言排除患者,导致少数群体的代表性不足. 解决这些障碍对于在癌症研究中公平招募患者至关重要.
科学领域:
- 在瘤学瘤学.
- 临床试验设计 临床试验设计
- 健康 公平 卫生 公平
背景情况:
- 在甲状腺癌治疗中存在种族和民族差异.
- 改善临床试验多样性是缓解这些差异的关键.
- 这项研究探讨了在甲状腺癌试验中公平代表性的障碍.
研究的目的:
- 评估甲状腺癌临床试验的试验资格标准和招生模式.
- 识别阻碍不同患者群体公平代表性的障碍.
- 评估排斥标准对少数民族入学的影响.
主要方法:
- 在ClinicalTrials.gov上搜索甲状腺癌治疗研究 (1993-2023年).
- 分析了纳入/排除标准,并报告了人口统计数据.
- 使用美国人口普查和SEER数据,比较观察到的入学率与预期的分布.
主要成果:
- 7.4%的试验基于语言排除了患者.
- 白人美国参与者占比过高 (O/E比:1.2).
- 亚裔/原住民夏威夷人,黑人和西班牙裔患者的比例不足 (O/E比率分别为0.6,0.6和0.2).
结论:
- 甲状腺癌试验中的语言排除标准限制了少数群体的入学.
- 观察到亚洲/夏威夷原住民,黑人和西班牙裔患者的代表性不足.
- 消除排斥标准和改善人口统计报告可以提高临床试验的公平性.
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