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静止剂使用轨迹 腹腔外科手术后:一个匹配的队列分析
Anyull D Bohorquez Caballero1, Elizabeth Wall-Wieler2, Yuki Liu2
1Division of Advanced GI And Bariatric Surgery, Mayo Clinic, Jacksonville, Florida.
概括
代谢和减肥手术 (MBS) 在肥胖患者中显著减少了他类药物的使用. MBS导致更少的人需要他类药物,更多的人停止服用,显示其在治疗失脂症方面的作用.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 腹部外科 腹部外科
背景情况:
- 代谢和减肥手术 (MBS) 是一种高效的长期治疗肥胖的方法.
- 肥胖是心血管疾病的重要危险因素,通常用他类药物进行治疗.
研究的目的:
- 在接受MBS之前和之后的患者中比较他类药物利用轨迹.
- 评估MBS对启动和停止他类药物治疗的影响.
主要方法:
- 美国雇主索赔数据库的回顾性分析.
- 将16359名接受MBS治疗的成年患者与16359名没有接受MBS治疗的同类患者进行匹配.
- 在索引日期后的两年内检查他类药物使用模式.
主要成果:
- 在基线他类药物使用者中,MBS组的60.4%在两年内停止服用他类药物,而非MBS组的35.4%.
- 对于未服用他类药物的人来说,MBS后仅有2.6%的人开始服用他类药物,而非MBS组的这一比例为9.6%.
- 在MBS队列中,他类药物的使用显著下降,从基线时的19.4%降至两年后的9.3%.
结论:
- 代谢和减肥手术 (MBS) 导致以前使用他类药物的患者在实质上停止使用他类药物.
- 在以前没有服用药物的个人中,MBS显著降低了启动他类药物治疗的可能性.
- 这些发现强调了MBS作为治疗和预防失脂症的关键干预措施.
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