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Updated: Jun 11, 2025

Endothelial Cell Co-culture Mediates Maturation of Human Embryonic Stem Cell to Pancreatic Insulin Producing Cells in a Directed Differentiation Approach
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Endothelial Cell Co-culture Mediates Maturation of Human Embryonic Stem Cell to Pancreatic Insulin Producing Cells in a Directed Differentiation Approach

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转录协活性剂MED15对于β细胞成熟是必需的

Alex Z Kadhim1,2,3, Ben Vanderkruk1,4, Samantha Mar1,4

  • 1Diabetes Research Program, BC Children's Hospital Research Institute, Vancouver, Canada.

Nature communications
|October 8, 2024
PubMed
概括

中介子单元MED15对于胰腺β细胞成熟至关重要. 它的缺席会损害发育,而它的存在会增强成熟标志物,这表明它在糖尿病研究中起着保留的作用.

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