一个新的GWAS位点影响微血管对精神压力的反应,并预测不良心血管事件
Zakaria Almuwaqqat1,2, Chang Liu1,2, Jeong Hwan Kim1
1Department of Medicine, Division of Cardiology, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, 1462 Clifton Road N.E. Suite 507, Atlanta, GA, 30322, USA.
Scientific reports
|October 8, 2024
概括
在冠状动脉疾病 (CAD) 患者的精神压力期间,遗传因素会影响微血管收缩. 特定的遗传变异与心血管事件风险增加有关,突出显示了压力诱导血管运动的遗传基础.
科学领域:
- 心血管遗传学 心血管遗传学
- 血管生理学 血管生理学
- 基因组医学是基因组医学.
背景情况:
- 在急性心理压力期间,过度的外周微血管收缩与冠状动脉血流变化和不良心血管结果有关.
- 患有冠状动脉疾病 (CAD) 的人可能在精神压力期间表现出对微血管反应的遗传倾向.
研究的目的:
- 研究基因因素对稳定的CAD个体在精神压力期间微血管收缩程度的贡献.
- 识别与压力诱导的微血管变化相关的遗传变异及其预后影响.
主要方法:
- 进行了全基因组关联研究 (GWAS),对580名稳定的CAD个体的脉冲波幅度的压力/休息 (sPAT) 比率进行了研究.
- 进行了种族分层和跨种族的元分析.
- 参与者被跟踪复发性心血管事件使用的韦-林-韦斯菲尔德 (WLW) 模型.
主要成果:
- 在链接不平衡的三个单核酸多态 (SNP),接近rs6466396,与sPAT比率 (p=6.68E-09) 有意义地相关.
- 对于rs6466396的T等位体具有同位素的个体,心血管不良事件的风险增加了80% (HR 1.8).
- 较低的sPAT比率与较高的不良事件率相关 (HR 1.3),尽管基因型调整没有显著改变这种影响.
结论:
- 在患有CAD的个体中,已经确定了压力诱导的血管运动的遗传基础.
- 三种相关的基因变异在精神压力期间调节血管收缩,可能对心血管结果具有预后意义.
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