日本成年人的相对脂肪量与糖尿病风险之间的非线性关系:一项回顾性队列研究
Binhui Xiao1, Changchun Cao2, Yong Han3,4
1Department of Neurosurgery, Shenzhen Yantian District People's Hospital, Southern University of Science and Technology Yantian Hospital, Shenzhen, 518081, Guangdong, China.
Scientific reports
|October 8, 2024
概括
相对脂肪量 (RFM) 与糖尿病风险有关,特别是在女性中. 降低RFM可能有助于预防糖尿病发病,特别是在两个性别的确定的值以上.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 人类测量学 人类测量学.
背景情况:
- 相对脂肪质量 (RFM) 是一种用于估计身体脂肪百分比的新型人体测量方法.
- 有限的研究存在于RFM和糖尿病 (DM) 风险之间的关联.
- 这项研究调查了日本人口中RFM和事件DM之间的关系.
研究的目的:
- 评估相对脂肪量 (RFM) 与患糖尿病 (DM) 的风险之间的相关性.
- 探索潜在的非线性关联,并确定有关日本成年人糖尿病风险的RFM值.
- 基于人体测量测量,提供关于糖尿病预防策略的见解.
主要方法:
- 从2004年到2015年,利用了15462名没有糖尿病的日本人的数据.
- 采用克斯的比例风险回归模型与立方线函数来分析RFM和发病糖尿病之间的非线性关系.
- 进行性别特异性分析和敏感性分析以验证发现.
主要成果:
- 在女性 (HR:1.13),但在男性 (HR:1.05) 中没有观察到RFM和糖尿病风险之间的显著积极关联.
- 在两种性别中都确定了非线性关系和值效应.
- 确定了RFM值:女性为39.23,男性为23.08,高于这些值的风险增加,尤其是男性 (HR:1.16).
结论:
- 在RFM和糖尿病风险之间存在非线性关系和值效应.
- 保持较低的RFM水平可能有助于缓解糖尿病发病.
- RFM作为糖尿病风险评估的有价值指标,特别是在超过特定值的女性和男性中.
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