环境肠道病变的儿童是否有饮食中的宏观营养素吸收不良?
Nirupama Shivakumar1,2, Douglas J Morrison3, Shalini G Hegde4
1Division of Nutrition, St. John's Research Institute, St. John's National Academy of Health Sciences (A Unit of CBCI Society for Medical Education), Bangalore, India.
European journal of clinical nutrition
|October 8, 2024
概括
儿童的环境肠病 (EE) 导致营养吸收不良,影响生长和认知. 非侵入性呼吸试验显示出评估碳水化合物和脂肪不良吸收的前景.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
- 环境健康 环境健康
背景情况:
- 在儿童中评估胃肠道 (GIT) 功能是非常具有挑战性的.
- 儿童环境肠病 (EE) 与生长迟缓,营养不良和认知障碍有关.
- 在EE中吸收不良是连接肠道功能障碍与这些不良结果的关键因素.
研究的目的:
- 审查EE中宏观营养素吸收不良的机制.
- 评估现有和潜在的非侵入性测试,以测量EE中的吸收不良.
- 讨论这些测试是否适用于患有EE的儿童.
主要方法:
- 机械学和实验研究的叙述性综述.
- 检查人类实验研究的优点和局限性.
- 对测量吸收不良现有和潜在测试的分析.
主要成果:
- 乳糖和脂肪的吸收不良在患有EE的儿童中很常见.
- 使用13C标记基质的非侵入性呼吸试验显示了评估碳水化合物,脂肪和二吸收不良的潜力.
- 修改的呼吸试验协议可能适用于患有EE的儿童.
结论:
- 非侵入性呼吸试验提供了一种可行的方法来评估儿童时期的吸收不良.
- 进一步的研究应该量化宏观营养素吸收不良,并将其与不同环境中的功能结果联系起来.
相关概念视频
Overview of Protein Metabolism
788
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
788
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
323
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
323
Enteral Nutrition I: Orogastric and Nasogastric Feeding
212
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
212
Lipid Absorption
392
Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
392
Carbohydrate Absorption
552
Carbohydrates are essential macronutrients that serve as the body's primary energy source. Their digestion begins in the mouth, where salivary amylase partially breaks down complex carbohydrates such as starch into smaller oligosaccharides. This mechanical and enzymatic activity prepares carbohydrates for further processing in the gastrointestinal tract.
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...
After being swallowed, the partially digested carbohydrates mix with gastric secretions in the stomach. However, the acidic environment...
552
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
83
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
83


