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Updated: Jun 11, 2025

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过度活跃的mTORC1/4EBP1信号失调蛋白质稳定,加速心脏衰老

Weronika Zarzycka1,2, Kamil A Kobak1, Catherine J King1

  • 1Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

GeroScience
|October 8, 2024
PubMed
概括

拉巴胺复合体1 (mTORC1)/4E结合蛋白1 (4EBP1) 轴的过度活跃的机械标加速了心脏衰老. 这种加速衰老与蛋白质稳定性受损有关,影响小鼠的心脏功能和表现.

关键词:
在4EBP1中.心脏衰老的心脏衰老蛋白质稳定性 蛋白质稳定性在mTOROR中使用mTOR.

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