川崎病在COVID-19大流行之前和期间:瑞士单中心比较研究
Justine Epitaux1, Nicole Sekarski2, Sabrina Bressieux-Degueldre3
1Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 21, Lausanne, 1011, Switzerland.
BMC pediatrics
|October 8, 2024
概括
在瑞士,川崎病的发病率在COVID-19大流行期间显著增加了88%. 这项研究强调了在大流行期间儿科炎症疾病的增加,与全球趋势形成鲜明对比.
科学领域:
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 川崎病是儿童获得心血管疾病的主要原因.
- 它的发病过程很复杂,怀疑病毒触发因素和遗传因素.
- 在COVID-19大流行期间,全球发病率趋势有所不同,一些研究报告说有所下降.
研究的目的:
- 评估COVID-19大流行对瑞士川崎病发病率的影响.
- 分析疾病特征的变化,冠状动脉结果和管理.
- 为了比较大流行期间前和期间的数据.
主要方法:
- 对被诊断患有川崎病的儿科患者的回顾性分析.
- 临床,实验室,SARS-CoV-2暴露和心声数据的比较.
- 从2017年1月到2022年12月收集的数据,包括大流行前和大流行期间.
主要成果:
- 川崎病的发病率在大流行期间增加了88% (5.91/100,000名儿童),与大流行前 (3.14/100,000名儿童) 相比.
- 观察到发生率显著增加 (p < 0.05).
- 30%的流行病例暴露于SARS-CoV-2;在人口统计,呈现或结果方面没有显著差异.
结论:
- 这是欧洲在COVID-19大流行之前和期间对川崎病发病率进行的首次长期研究.
- 瑞士的发病率显著增加,与其他国家的调查结果形成鲜明对比.
- 方法学,遗传学,环境和SARS-CoV-2传播等因素可能解释不同的国际趋势.
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