对于多性冠状动脉血管病变的内静脉康伯塞普治疗的两年结果
Yang Liu1,2,3, Jingli Guo4, Wenyi Tang1,2,3
1Department of Ophthalmology, Eye and ENT Hospital of Fudan University, No.83, Fen Yang Road, Shanghai, 200031, China.
BMC ophthalmology
|October 8, 2024
概括
在两年内,Conbercept有效治疗了多性胆道血管病变 (PCV),改善视力和减少视网膜厚度. 治疗反应的预测因素包括分支血管网络血管密度和亚黄斑出血.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 血管生物学 血管生物学
背景情况:
- 多性冠状血管病变 (PCV) 是一种常见的与年龄相关的黄斑变性的一种亚型.
- 对PCV有效的治疗策略对于维护视觉功能至关重要.
研究的目的:
- 评估在PCV.患者中使用conbercept治疗的两年后的结果.
- 确定PCV患者治疗反应的预测因素.
主要方法:
- 连续接受内康伯塞普的PCV患者的回顾性研究.
- 评估最佳校正的视力敏度 (BCVA),中枢视网膜厚度 (CRT) 和多状况.
- 根据6个月的斑点状况分类为"干燥"或"非干燥"组,以确定预测因素.
主要成果:
- 在24个月后,BCVA显著改善,CRT减少 (p<0.05).
- 88%的眼睛获得了干燥的斑点,聚消失率为63.6% (p<0.001).
- 较高的分支血管网络血管密度 (BVN VD),亚黄斑出血,以及没有与多相关的PED预测了干燥斑点反应.
结论:
- 在两年内,Conbercept在维持PCV的功能和解剖改善方面表现出有效性.
- 基线特征如BVN VD,血清性PED的息肉的存在,以及亚黄斑出血似乎影响了对conbercept的治疗反应.
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