体重变化与所有原因和特定原因死亡率的关联:年龄分层分析
Qing-Mei Huang1, Dong Shen1, Jian Gao1
1Department of Epidemiology, School of Public Health, Southern Medical University, No. 1023-1063, Satai South Road, Baiyun District, Guangzhou, Guangdong, 510515, China.
BMC medicine
|October 8, 2024
概括
显著的体重减轻和增加增加了老年人死亡风险. 中年成年人面临更高的死亡风险,只有从大量的体重减轻,突出体重变化的年龄特异性影响.
科学领域:
- 老年学与公共卫生
- 流行病学 流行病学
- 心血管研究研究心血管研究
背景情况:
- 不同年龄组体重波动与死亡率之间的关系需要进一步研究.
- 了解这些关联对于有针对性的健康干预至关重要.
研究的目的:
- 检查中国成年人体质指数 (BMI) 变化与死亡风险之间的年龄分层关联.
- 区分对所有原因,非传染性疾病,心血管疾病 (CVD) 和癌症死亡率的影响.
主要方法:
- 来自深医疗保健大数据队列的746,991名中国成年人 (≥45岁) 的大型队列研究.
- 体重指数变化的分类:稳定,5-10%的下降,>10%的下降,5-10%的增加,>10%的增加.
- 考克斯的比例危险模型被用来估计死亡风险,调整了混因素.
主要成果:
- 观察到年龄和体重变化之间存在显著的相互作用.
- 在65岁以上的成年人中,>10%的BMI下降增加了全因死亡风险 (HR:1.69),以及非传染性疾病,心血管疾病和癌症的风险.
- >10%的BMI增加也增加了全因死亡风险 (HR:1.13),非传染性疾病和心血管疾病死亡率.
- 在65岁以下的成年人中,只有10%以上的BMI下降与增加的全因死亡率 (HR:1.41),非传染性疾病和癌症死亡率有关.
结论:
- 减肥和过度增加体重与老年人死亡率的增加有关.
- 对于中年成年人来说,只有显著的体重减轻与死亡风险增加有关.
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