益生菌可以引发卫生保健环境清洁的范式转变吗? 一个叙事审查
Luisa A Denkel1,2, Andreas Voss3, Elisabetta Caselli4
1Institute of Hygiene and Environmental Medicine, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Hindenburgdamm 27, 12203, Berlin, Germany. luisa.denkel@charite.de.
Antimicrobial resistance and infection control
|October 8, 2024
概括
益生菌清洁产品为医疗环境提供了化学消毒剂的可持续替代品,有效减少病原体和抗菌素耐药性. 需要进一步的研究来标准化产品,并确认它们对医疗保健相关感染的影响.
科学领域:
- 微生物学 微生物学
- 感染控制 感染控制
- 环境卫生环境卫生
背景情况:
- 医疗保健环境对于多种耐药生物体 (MDRO) 传播和与医疗保健相关的感染 (HAI) 来说至关重要.
- 益生菌清洁产品为环境卫生提供了一个新的,可持续的和可生物降解的选择.
- 这些产品为控制微生物负载和防止病原体传播提供了传统化学消毒剂的替代品.
研究的目的:
- 总结当前关于医疗保健机构中益生菌清洁的证据.
- 与传统消毒剂相比,评估益生菌清洁的有效性.
- 确定益生菌环境卫生方面的知识缺口和未来的研究需求.
主要方法:
- 感染控制专家综合了已发表的随机临床试验 (RCT) 和现有文献数据,直到2023年6月.
- 进行了对益生菌清洁疗效研究的审查,包括环境和临床结果.
- 在等待进一步的强有力的研究和元分析之前,制定了专家建议.
主要成果:
- 益生菌清洁在减少环境样本中的HAI病原体,病毒 (例如,SARS-CoV-2) 和MDROs方面表现出与化学消毒剂相比较的有效性.
- 一个大型的RCT表明,在预防HAI方面,益生菌清洁与消毒剂无差.
- 益生菌清洁还显示出降低抗微生物耐药性基因 (ARG),成本和抗微生物消耗的潜力,同时可生物降解,对职业健康更安全.
结论:
- 益生菌清洁代表了医院环境中化学消毒剂的突破性生物替代品,可能会影响MDRO传播.
- 需要对各种益生菌产品成分进行标准化,并生成更强大的临床数据.
- 这些进步可以促进对医疗保健环境卫生中的生物控制的范式转变.
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