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Updated: Jun 11, 2025

A Nonsequencing Approach for the Rapid Detection of RNA Editing
08:50

A Nonsequencing Approach for the Rapid Detection of RNA Editing

Published on: April 21, 2022

2.6K

测量:一个深度学习模型嵌入式框架,以区分RNA编辑和DNA突变在RNA测序数据中的RNA编辑

Zhi-Can Fu1,2, Bao-Qing Gao1,2, Fang Nan1

  • 1Center for Molecular Medicine, Children's Hospital of Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.

Genome biology
|October 8, 2024
PubMed
概括

本研究介绍了DEMINING,这是一种计算工具,用于区分RNA编辑与DNA突变在测序数据中的区别. 它识别了白血病中新的RNA编辑和DNA突变部位,其中一些与基因表达和新抗原产生有关.

关键词:
在AML,AML就是AML.基因突变是一种DNA突变.深度学习是一种深度学习.这是一个IDR IDR.新抗原是一种新抗原.编辑RNA的RNA编辑在RNA-seqqq.转移学习转移学习

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RNA Editing02:23

RNA Editing

RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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