环境污染对某些类风湿性疾病的严重程度的影响:对炎症和非炎症样本进行比较分析研究
Adel Elbeialy1, Soaad El Sawy2, Hala Elzomor2
1Rheumatology and Rehabilitation, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt. aelbeialy@azhar.edu.eg.
BMC rheumatology
|October 8, 2024
概括
慢性重金属毒性与风湿性关节炎 (RA) 和纤维肌痛综合征 (FMS) 患者的维生素D3 (VD) 缺乏和副甲状腺激素 (PTH) 失衡有关. 这表明重金属可能有助于这些条件的发展和活动.
科学领域:
- 环境毒理学环境毒理学
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
背景情况:
- 由于对健康的不利影响,重金属对环境的污染是全球日益关注的问题.
- 暴露于重金属与类风湿性关节炎 (RA) 和纤维肌痛综合征 (FMS) 等疾病有关.
- 在患有炎症和非炎症性疾病的患者中,经常观察到维生素D3 (VD) 缺乏和副甲状腺激素 (PTH) 障碍.
研究的目的:
- 调查慢性重金属毒性在诱导维生素D3 (VD) 缺乏症中的作用.
- 评估重金属对类甲状腺激素 (PTH) 在类风湿性关节炎 (RA) 和纤维肌痛综合征 (FMS) 的水平的影响.
- 评估重金属与RA和FMS中的疾病活性之间的关联.
主要方法:
- 一项涉及60名成年人 (≥18岁) 的比较分析研究,分为三个组:RA患者 (n=20),FMS患者 (n=20) 和健康对照 (n=20).
- 参与者接受了例行实验室检测,包括测量PTH,VD和血清中,和水平.
- 使用的诊断标准是RA的ACR/EULAR和FMS的2010 ACR.
主要成果:
- 在RA和FMS组中,维生素D3 (VD) 水平与PTH,,,和疾病活性得分显著反相关.
- ,和被确定为RA患者体内血管缺陷的重要独立风险因素.
- 发现暴露是FMS患者体内血管缺陷的重要独立风险因素.
结论:
- 长期暴露于重金属可能会损害维生素D3 (VD) 合成,导致低维生素D和RA和FMS中的二次性甲状腺功能增强症.
- 重金属似乎在类风湿性关节炎 (RA) 和纤维肌痛综合征 (FMS) 的病原和疾病活性中发挥着至关重要的作用.
- 这些发现凸显了环境重金属暴露对风湿症和疼痛综合征的发展和进展的潜在影响.
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