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Updated: Jun 11, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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普罗罗丁-5:一种来自本土海洋恐龙鞭状物Prorocentrum lima的细胞毒性多基化物

Yunseok Choi1, Eun Ju Jeong2, Yeong Du Yoo1

  • 1Department of Oceanography, Kunsan National University, 558 Daehak-ro, Gunsan 54150, South Korea.

Journal of natural products
|October 9, 2024
PubMed
概括

来自海洋恐龙虫的化合物prorocentin-5通过诱导细胞死亡和阻止癌细胞分裂,显示出强大的抗癌活性. 这种海洋天然产品为癌症研究和药物开发提供了有前途的途径.

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Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks

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Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
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Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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Bacterial Phylum Planctomycetes

Planctomycetes are a group of morphologically distinct bacteria predominantly classified into two orders: Planctomycetales and Brocadiales. These gram-negative bacteria exhibit unique features, including division by budding and the presence of stalks or appendages. Their cells are often found in rosette arrangements, and they are notable for possessing an S-layer in their cell envelope, which is relatively uncommon among bacteria. Additionally, Planctomycetes frequently exhibit intracellular...