在酒精使用行为各个维度上的遗传异质性
Jeanne E Savage1, Peter B Barr1, Tanya Phung1
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam (Savage, Phung, Posthuma); Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, New York (Barr, Meyers, Porjesz); VA New York Harbor Healthcare System, Brooklyn, New York (Barr, Meyers); Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine (Lee, Zhang, Ge, Smoller, Mallard), and Center for Precision Psychiatry (Ge, Smoller), Massachusetts General Hospital, Boston; Department of Psychiatry, Harvard Medical School, Boston (Lee, Ge, Smoller, Mallard); Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge (Lee, Zhang, Ge, Smoller, Mallard); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Zhang); Department of Psychiatry, Washington University School of Medicine, St. Louis (McCutcheon); Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville (Davis, Sanchez-Roige); Department of Child and Adolescent Psychology and Psychiatry, section Complex Trait Genetics, VU University Medical Center, Amsterdam (Posthuma); Department of Psychiatry and Institute for Genomic Medicine, University of California San Diego, La Jolla (Sanchez-Roige).
这项研究在40万名英国生物银行参与者中确定了四种酒精使用行为 (AUB) 的遗传因素. 了解AUBs的使用方法
科学领域:
- 遗传学 是一个遗传学.
- 行为科学 行为科学
- 精神病学是一个精神病学.
背景情况:
- 对酒精使用行为 (AUB) 的全基因组关联研究 (GWAS) 已经确定了许多基因,但临床和功能理解是有限的.
- 现有的GWAS通常忽视了AUB的复杂和异质性质,阻碍了遗传解释.
研究的目的:
- 通过使用一个多维的框架来调查各种酒精使用行为的潜在遗传结构.
- 确定影响AUBs各个维度的潜在遗传因素.
主要方法:
- 利用来自约40万英国生物库参与者的多式评估,涵盖18个不同的AUB.
- 针对个别的AUB进行了GWAS,并采用了基因组结构方程建模来识别潜在的遗传因素.
- 执行功能注释,遗传相关性和丰富分析以解释遗传关联.
主要成果:
- 确定了四个潜在的遗传因素:问题,消费,酒Pref和非典型Pref.
- 这些因素表现出温和的遗传相关性和明显的关联模式,BeerPref涉及新的基因组区域.
- 通过潜伏因素观察到大脑中区域和细胞类型特定基因表达的差异.
结论:
- 深度表型是促进对AUBs遗传病因学的理解至关重要的.
- 需要进一步研究采用捕捉AUB多维性质的方法,以解开它们的遗传异质性.
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