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Updated: Jun 11, 2025

An In Vitro Assay to Detect tRNA-Isopentenyl Transferase Activity
07:46

An In Vitro Assay to Detect tRNA-Isopentenyl Transferase Activity

Published on: October 8, 2018

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氨酸低基改造是线粒体tRNATrp相关遗传疾病的基础

Jia-Li Lu1, Yichen Dai2, Kunqian Ji3

  • 1Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China.

Nucleic acids research
|October 9, 2024
PubMed
概括

线粒体DNA突变可以通过影响转移RNA (tRNA) 修改引起遗传疾病. 这项研究揭示了MT-TW基因的突变导致人类线粒体tRNA (hmtRNAs) 中 taurine-thylated uridine (τm5U) 的低修饰,影响线粒体翻译.

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