微Epitope:来自癌症微生物组的免疫表位图集
Donghao Li1, Yangyang Cai1, Kefan Liu2
1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province 150081, China.
Nucleic acids research
|October 9, 2024
概括
微Epitope数据库提供了人类癌症中微生物表位的全面地图. 本资源有助于理解微生物成分如何影响癌症免疫力,有助于识别潜在的瘤抗原.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 生物信息学是一种生物信息学.
背景情况:
- 内微生物群在人类癌症中普遍存在.
- 微生物群衍生的表位体可以模仿瘤抗原,通过人类白细胞抗原 (HLA) 结合影响宿主免疫力.
- 癌症中微生物群与宿主免疫相互作用的机制需要进一步阐明.
研究的目的:
- 开发和介绍MicroEpitope,这是一个数据库资源,用于分析癌症中微生物群衍生的表位.
- 提供与癌症免疫相关的微生物表位的全面地图.
- 促进研究微生物群在癌症免疫学中的作用.
主要方法:
- 从24种类型的1190个癌症样本中手动收集基于质谱 (MS) 的HLA免疫.
- 与人类和内微生物群蛋白 (1298种细菌,124种病毒) 的理论库对齐.
- 对表位免疫性特征,生化特性和相关微生物的临床相关性进行分析.
主要成果:
- 微Epitope数据库目前包含51,497个来自细菌的和767个来自病毒的表位.
- 主要的表位源包括Bacillus subtilis,Buchnera aphidicola和人类细胞巨乳病毒.
- 数据库包括分析工具和可视化方法,用于探索癌症免疫中的微生物群衍生的表位.
结论:
- 微Epitope作为研究癌症微生物组的HLA呈现免疫的关键资源.
- 该数据库可以提供有关瘤抗原优先级策略的见解.
- 有助于更深入地了解癌症,微生物组和免疫系统之间的相互作用.
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