含有连接体的和银复合物:合成,结构研究,生物活性和对接研究
Azza A Hassoon1, Stacey J Smith2, Roger G Harrison2
1Chemistry Department, Faculty of Science, Mansoura University Mansoura 35516 Egypt azza_ahmed@hotmail.com azza_ahmed@mans.edu.eg.
RSC advances
|October 9, 2024
概括
合成了七种新的金属协调复合物,用于生物医学用途. 三核银复合体Q3对乳腺癌细胞具有显著的潜力,显示出强大的抗癌活性.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 药用化学 医学化学
背景情况:
- 金属协调复合体在医学上提供了多样化的应用.
- 像2,4,6-tris-(2-pyridyl) -1,3,5-triazine (TPT) 这样的含氨酸的配体在合成新型化合物中具有价值.
- 探索 (II) 和银 (I) 复合物的生物活性.
研究的目的:
- 使用TPT连接体合成和表征新型金属协调复合物 (Q1-Q7).
- 研究合成复合物的结构,光谱,发光和电化学特性.
- 评估复合物的体外抗菌,抗真菌和抗癌活性.
主要方法:
- 合成单核,多核和Cd (II) 和Ag (I) 的混合联结体复合体.
- 使用IR,UV-Vis,NMR (1D和2D),CHN分析,摩尔导电,TGA和X射线衍射进行表征.
- 对MCF-7细胞系的体外抗菌和抗真菌功效以及抗癌活性的评估.
- 针对CDK2,CDK6,STAT3和β-乳酸酶的分子对接模拟.
主要成果:
- 七个新的协调复合体 (Q1-Q7) 已成功合成和表征.
- 复杂的Q6结构通过单晶X射线分析得到证实,揭示了Ag (I) 周围扭曲的三角形双金字塔几何.
- 复合Q3 (三核银) 对MCF-7细胞具有显著的抗癌活性,IC50为13.45 ± 0.9μM.
- 分子对接表明与关键癌症和细菌蛋白质的潜在相互作用.
结论:
- 合成的金属复合物具有有前途的生物医学潜力.
- 三核银复合体Q3是乳腺癌治疗的强有力的候选者.
- 需要进一步的研究来探索这些新型协调化合物的治疗应用.
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