乳腺组织中由肥胖驱动的变化表现出一种亲血管性细胞外矩阵特征
Ellen E Bamberg1, Mark Maslanka2, Kiran Vinod-Paul1
1Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Matrix biology plus
|October 9, 2024
概括
肥胖与乳腺癌风险和不良结果有关. 这项研究确定了特定的细胞外矩阵蛋白质,如过氧化素, galectin-1 和 galectin-3,这些蛋白质在肥胖个体中发生了变化,可能导致癌症的进展.
科学领域:
- 在瘤学瘤学.
- 代谢综合征是代谢综合征的一种.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 肥胖是乳腺癌发病和不良后果的重要危险因素.
- 肥胖和乳腺癌都涉及细胞外基质 (ECM) 的改变.
- 关联肥胖,ECM变化和乳腺癌的确切机制尚不清楚.
研究的目的:
- 研究不同类别的身体质量指数 (BMI) 乳腺组织中的细胞外矩阵 (ECM) 蛋白质变化.
- 确定潜在的ECM修饰蛋白质,这些蛋白质有助于肥胖个体的乳腺癌发展和进展.
主要方法:
- 总乳腺组织蛋白质组学被用来分析正常体重,超重和肥胖个体的样本.
- 进行了相关性分析,以将已识别的蛋白与血管和底层膜特征联系起来.
- 评估了与介质干细胞标记物的关联,以确定ECM变化的细胞起源.
主要成果:
- 肥胖个体表现出显著的ECM变化,包括增加底层膜沉积和血管生成特征.
- 氧化素 (PXDN),加勒-1 (LGALS1) 和加勒-3 (LGALS3) 被确定为关键的ECM修饰蛋白与肥胖相关.
- 乳腺癌中PXDN,LGALS1和LGALS3的水平升高与无复发和远程转移无复发的生存率降低有关.
- 这些蛋白质与脂肪细胞和纤维细胞有关,这表明它们在与肥胖相关的ECM变化中的作用.
结论:
- 在肥胖个体的乳腺组织中存在一种亲血管性ECM特征.
- 在肥胖的背景下,PXDN,LGALS1和LGALS3代表了抑制乳腺癌发展和进展的潜在治疗标.
关键词:
脂肪细胞是一种脂肪细胞.身体质量指数 (BMI) 是指身体质量指数.乳房 乳房 乳房细胞外矩阵是细胞外矩阵.纤维细胞细胞.盖莱丁是一种质素.在LGALS1中在LGALS3中肥胖问题 肥胖问题在PXDNN中使用PXDNN.氧化素的使用干细胞是干细胞的细胞.组织蛋白质组学瘤微环境 瘤微环境更多相关视频
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