可食用大麻治疗慢性腰部疼痛:与疼痛,情绪和中毒有关联
Samantha N Melendez1, Marco Ortiz Torres2, Jonathan K Lisano1
1Department of Psychology and Neuroscience, College of Arts and Sciences, University of Colorado Boulder, Boulder, CO, United States.
Frontiers in pharmacology
|October 9, 2024
概括
这项研究发现,食用食品中的delta-9-tetrahydrocannabinol (THC) 为慢性腰部疼痛提供了短期的疼痛缓解. 大麻素 (CBD) 提供了缓解紧张的方法,而CBD主导的食用食品可能会在两周内改善疼痛.
科学领域:
- 医学研究 医学研究
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 大麻越来越容易用于治疗,特别是慢性疼痛.
- 合法大麻食用品对慢性腰部疼痛 (CLBP) 的有效性尚不清楚.
- 需要对可食用形式的THC和CBD等特定大麻素进行研究.
研究的目的:
- 研究可食用大麻产品在治疗慢性腰痛方面的有效性.
- 评估delta-9-tetrahydrocannabinol (THC) 和cannabidiol (CBD) 剂量对疼痛,情绪和主观影响的影响.
- 评估CLBP患者自选食用大麻使用的短期和两周的疼痛缓解.
主要方法:
- 自然主义的前性研究设计,包括249名被诊断患有CLBP的参与者.
- 参与者自行选择食用大麻产品 (CBD主导,THC主导或组合).
- 数据是在两周的随意使用和急性服用期间收集的.
主要成果:
- 更高的THC剂量与更大的短期疼痛减轻相关 (p < .05).
- 摄入THC与增加的主观药物效应有关 (p < .001).
- CBD剂量与缓解紧张关系,而不是急性疼痛减轻;CBD占主导地位的食用食品在两周内显示出更大的疼痛减轻趋势 (p = .07).
结论:
- 研究结果支持THC的短期止痛作用和CBD的抗焦虑作用.
- 口服THC和CBD显示出潜在的急性和延长缓解慢性腰部疼痛.
- 需要进一步评估用于CLBP管理的食用配方中的THC和CBD.
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