在动物自闭症模型中,益生菌减少了与GABA受体基因表达相关的肠道泄漏:强调肠-大脑轴的重要性
Rawan M Bin-Khattaf1, Abeer M Al-Dbass1, Mona Alonazi1
1Biochemistry Department, Science College, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia.
Translational neuroscience
|October 9, 2024
概括
益生菌可能有助于降低自闭症谱系障碍模型中的肠道透性和氧化应激. 这项研究表明,益生菌可以改善肠道屏障功能和GABA信号传递,提供潜在的治疗益处.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 自闭症谱系障碍 (ASD) 经常与胃肠道 (GI) 问题有关.
- 增加了肠道的透性,或增加了肠道的透性.
- 有泄漏的肠道
- 在ASD中是一种潜在的并发症.
- 动物模型提供了一种方法来研究ASD的肠-大脑轴.
研究的目的:
- 在动物模型中研究益生菌对肠道透性和神经毒性的影响.
- 评估益生菌是否可以减轻酸 (PPA) 暴露对肠道屏障功能和氧化应激的影响.
- 评估益生菌对胺黄油酸 (GABA) 受体表达的影响.
主要方法:
- 40只年轻的雄性大鼠被分为六组,其中一些暴露在酸 (PPA) 中以诱导神经毒性.
- 治疗组接受了口服*Bifidobacterium infantis*,*Lactobacillus bulgaricus*或益生菌混合物三周的治疗.
- 测量包括血清佐努林,奥克卢丁,谷氨,马隆迪化,酶和GABA受体基因表达.
主要成果:
- 益生菌显著降低佐努林和奥克卢丁的水平,表明改善了肠道屏障功能.
- 益生菌治疗增强了GABA受体表达.
- 氧化应激标志物 (谷氨,马隆迪甲基,催化酶) 被益生菌有利地调节.
结论:
- 各种益生菌对肠道屏障完整性表现出保护作用.
- 益生菌可以缓解增加的肠道透性和由PPA神经毒性引起的氧化应激.
- 这些发现支持益生菌补充剂的临床潜力,用于管理与ASD相关的胃肠道和神经症状.
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