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在温度中立状态下养的小鼠中,原子处理会增加能量消耗
Daniel G Sadler1,2,3, Reid D Landes2,4, Lillie Treas1,2
1Arkansas Children's Nutrition Center, Little Rock, AR, United States.
Frontiers in physiology
|October 9, 2024
概括
在30°C时,原孔处理显著增加了小鼠的能量消耗,但房温度会影响结果. 这凸显了在评估针对能源支出的抗肥胖药物时需要考虑环境温度的必要性.
科学领域:
- 代谢生理学 代谢生理学
- 药理学 药理学是指药理学的学科.
- 肥胖问题研究研究
背景情况:
- 亚热中性住房 (30°C) 提高了小鼠的选择性热生成.
- 这可能会掩盖针对能源支出 (EE) 的抗肥胖策略的有效性.
研究的目的:
- 为了研究原孔治疗对30°C的老鼠全身能量的影响.
- 为了确定原光子处理是否可以克服与热中性外相关的减少EE.
主要方法:
- 在C57BL/6J小鼠体内,温度为24°C,然后过渡到30°C.
- 在30°C的小鼠接受了对照水或补充了2,4-Dinitrophenol (DNP) 的水.
- 总EE (TEE) 和基底EE (BEE) 通过呼吸气体交换进行测量.
主要成果:
- 过渡到30°C降低了TEE和BEE分别为16%和41%.
- 与30°C对照组相比,DNP治疗增加了TEE的2.6千卡/天和BEE的1.2千卡/天.
- DNP治疗使女性的身体脂肪减少了2.9个百分点,部分原因是 inguinal 白脂肪质量减少.
结论:
- 在30°C的小鼠中,原孔治疗显著增加了EE.
- 来自DNP的EE增加小于移动小鼠到30°C所造成的减少.
- 在评估针对小鼠EE的抗肥胖策略时,住房温度是关键因素.
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