甘油三糖指数与肉症的关联:NHANES 2011-2014年
1Department of Endocrinology, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China.
Frontiers in endocrinology
|October 9, 2024
概括
甘油三糖 (TyG) 指数显示,与肌肉质量低,肌肉强度低和肉症有显著的正相关性. 这表明,TyG指数可能作为一种早期查工具来发现肉症风险.
科学领域:
- 老年学是一门学科.
- 代谢健康 代谢健康
- 肌肉骨健康 肌肉骨健康
背景情况:
- 胰岛素耐药性 (IR) 越来越令人担忧,甘油三指数 (TyG) 作为HOMA-IR更简单的替代品来识别.
- 关于TyG指数与肌肉健康指标之间的关联,特别是美国人口的低肌肉质量 (LMM),低肌肉强度 (LMS) 和肉症之间的研究有限.
研究的目的:
- 调查TyG指数与LMM,LMS和肉症的患病率之间的关系.
- 探索TyG指数作为查萨科佩尼亚的查工具的潜力.
主要方法:
- 利用了2011年至2014年国家健康和营养检查调查 (NHANES) 2,504名参与者的数据.
- 作为结果变量,分析了TyG指数与LMM,LMS和肉眼症之间的关联,并对潜在的混因素进行了调整.
- 采用平滑曲线拟合和两部分线性回归模型来确定相关性的性质.
主要成果:
- 在对所有变量进行调整后,TyG指数与LMM (OR=1.63),LMS (OR=1.61) 和肉症 (OR=1.59) 的患病率有显著的正相关性.
- 观察到TyG指数与LMM,LMS和肉症的患病率之间存在反转的U形相关性.
- 亚组分析表明,这种关联在所有性别,年龄组和正常BMI (≤25) 个体中都是一致的.
结论:
- 在TyG指数和肉症之间存在显著的积极关联.
- 泰格指数显示,作为一种有价值的查工具,可用于早期识别患有沙科佩尼亚风险的个体.
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