女性不孕症和中风死亡率之间的关联:来自PLCO癌症查试验的证据
Hui Tang1,2,3, Xueming Yang1, Zhou Li1,2,3
1Department of Neurosurgery, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China.
Frontiers in endocrinology
|October 9, 2024
概括
不孕症与女性中风死亡风险更高有关. 这项研究发现,有不孕症史的女性面临死于中风的可能性增加.
科学领域:
- 流行病学 流行病学
- 心血管健康 心血管健康
- 生殖健康 生殖健康
背景情况:
- 不孕症影响着相当一部分生育年龄的女性.
- 不孕症的长期后果,特别是关于中风死亡率的长期后果,尚不清楚.
- 了解这种关联对于妇女的长期健康管理至关重要.
研究的目的:
- 调查前史不孕症与绝经后妇女中风死亡风险之间的关联.
- 利用大规模癌症查试验的数据进行可靠的分析.
主要方法:
- 在前列腺,肺部,结肠直肠和卵巢 (PLCO) 癌症查试验中,分析了75778名年龄在55-74岁的女性参与者的数据.
- 平均随访时间为16.84年,以确定中风死亡事件.
- 考克斯的比例危险模型用于估计危险比率 (HRs) 和95%置信区间 (CI),并对许多潜在的混因素进行调整.
主要成果:
- 14.53%的参与者报告不孕.
- 在不孕症和中风死亡率增加之间观察到统计学上显著的关联 (HR 1.21,95% CI 1.04-1.41).
- 在对各种人口统计,生活方式和病史因素进行全面调整后,这种关联仍然存在 (调整后HR为1.20,95%CI为1.02-1.42).
结论:
- 不孕症与女性中风死亡率的风险增加有关.
- 这些发现突显了不孕不育对健康的潜在长期影响.
- 需要进一步的研究来探索与不孕症和中风风险相关的潜在生物和临床机制.
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