相关实验视频
Updated: Jun 11, 2025
13:28
Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
27.5K
在喘恶化中,2型和非2型炎症的生物标志物
Kosar M Ali1, Nsar Jamal1, Shukur Wasman Smail2,3
1Department of Medicine, Microbiology/Immunology, College of Medicine, University of Sulaimani, Iraq.
Central-European journal of immunology
|October 9, 2024
概括
成年人喘恶化显示T2和非T2炎症标志物升高. 干白素-17 (IL-17) 和IL-31水平区分严重的喘,并区分病毒和非病毒触发物.
科学领域:
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
- 过敏 过敏是一种过敏.
背景情况:
- 成人发作的喘呈现出不同的内型:T2 (eosinophilic) 和非T2 (neutrophilic,IL-17-驱动).
- 在恶化期间了解内型标志物对于严重喘管理至关重要.
- 在恶化中区分病毒和非病毒触发因素可能有助于制定治疗策略.
研究的目的:
- 分析住院严重喘患者的内型标志物概况.
- 要区分喘恶化病毒和非病毒触发因素.
- 为了确定严重喘和感染类型的生物标志物.
主要方法:
- 在恶化期间招募了49名喘患者和51名健康对照.
- 测量了血液中的乙氨基,乙氨基酸蛋白 (ECP),免疫球蛋白E (IgE),三酶,IL-17,IL-33和IL-31.
- 根据鼻口腔抽样,将患者分为病毒性 (n=11) 和非病毒性 (n=38) 感染组.
主要成果:
- 与对照组相比,喘患者表现出较高的乙氨基酸,ECP,IgE,三酶,IL-17,IL-31和IL-33.
- IL-17与其他炎症调解剂有很强的相关性,包括ECP,IgE,IL-33和IL-31.
- 免疫球蛋白E (IgE),IL-17和IL-31有效地区分了严重的喘和不严重的喘.
- 与非病毒性恶化相比,病毒性恶化与血清IL-17和IL-31水平升高有关.
结论:
- 喘恶化涉及T2和非T2炎症标志物的升高.
- IgE,IL-17 和 IL-31 作为区分严重喘的关键生物标志物.
- 在喘恶化中,IL-17和IL-31对于区分病毒和非病毒触发物是有价值的.
相关概念视频
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:20Asthma: Pathogenesis and Management
363
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
363
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:24Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
61
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
61