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准血清标记物介素9可以改善类风湿性关节炎的基本特征和免疫平衡

Ying Xiong¹, Wang Xiang², Wei Xiao²

¹Department of Rheumatology and Immunology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Central-European journal of immunology

|October 9, 2024

概括

介质蛋白9 (IL-9) 显示出作为血清阴性类风湿性关节炎 (SNRA) 的诊断标记物具有前途. 抑制IL-9通过调节免疫反应和炎症,有效地减少了大鼠模型中的关节炎严重程度.

科学领域:

免疫学免疫学免疫学
类风湿病学类风湿病学
生物化学生物化学

背景情况:

类风湿性关节炎 (RA) 诊断通常依赖于类风湿性因素 (RF) 和抗素化抗体 (ACPA).
一个被称为血清阴性RA (SNRA) 的RA患者子组缺乏这些传统的血清学标志物.
确定SNRA可靠的生物标志物对于准确的诊断和有效的治疗至关重要.

研究的目的:

为了研究Interleukin 9 (IL-9) 作为血清阴性类风湿性关节炎 (SNRA) 的诊断标记物的潜力.
在临床前模型中评估IL-9抑制对关节炎严重程度和免疫细胞调节的治疗效果.

主要方法:

从SNRA患者的血清样本和由原诱导的关节炎 (CIA) 的大鼠模型中分析了IL-9水平.
重组性大鼠IL-9 (rrIL-9) 和抗大鼠IL-9中和单克隆抗体 (mAb) 对关节炎严重程度,免疫细胞群 (Treg,Th17,M1/M2巨细胞) 和细胞因子水平的影响在CIA大鼠中进行了评估.

主要成果:

与健康对照组相比,在SNRA患者中观察到IL-9水平升高.
在CIA大鼠中,IL-9被确定为RA诊断的敏感标记物,与关节炎得分增加和关节损伤相关.
IL-9加剧了关节炎,而IL-9抑制改善了症状,促进了Treg/Th17平衡,将巨细胞偏向转向M2,并减少了炎症类细胞因子.

结论:

介素9 (IL-9) 显示出作为一种新型诊断生物标志物的潜力,用于血清阴性类风湿性关节炎 (SNRA).
向IL-9提供了一个有希望的治疗策略,通过调节Treg/Th17和巨细胞反应来减少RA相关的炎症和免疫失调.

关键词:

它们有IL-9和IL-9.这是一种炎症炎症炎症炎症.类风湿性关节炎 (RA) 是一种血清阴性类风湿性关节炎 (SNRA)血清标志物的血清标志物

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