类风湿性关节炎患者甲状腺功能障碍的危险因素
Lan Li1, Fuda Jiao2, Jinmei Zhao3
1Department of Rheumatology and Autoimmunology, Hebei Port Group Co., LTD. Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine, Qinhuangdao 066000, China.
Central-European journal of immunology
|October 9, 2024
概括
类风湿性关节炎患者患甲状腺功能障碍,特别是甲状腺功能低下的风险更高. 血红蛋白和总胆固醇水平被确定为关键风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 类风湿性关节炎 (RA) 是一种自身免疫性疾病,具有潜在的全身并发症.
- 甲状腺功能障碍是在自身免疫性疾病中已知的并发症.
研究的目的:
- 为了调查甲状腺功能障碍在RA患者的患病率.
- 在这个人群中识别与甲状腺功能障碍相关的危险因素.
主要方法:
- 对290名RA患者和200名健康对照患者的临床和实验室数据的回顾性分析.
- 测量甲状腺功能测试,抗甲状腺抗体和常规实验室参数.
- 后勤分析以确定甲状腺功能障碍的风险因素.
主要成果:
- 甲状腺功能障碍的患病率在RA患者中明显高 (30.0%) 与对照组 (7.0%) 相比.
- 关节炎患者表现出较低的总三甲氨酸 (T3) 和自由三甲氨酸 (FT3),以及较高的甲状腺激素 (TSH),抗甲状腺过氧化酶抗体 (TPOAb) 和抗甲状腺球蛋白抗体 (TgAb) 的水平.
- 血红蛋白 (HGB) 和总胆固醇 (TC) 水平在有或没有甲状腺功能异常的RA患者之间有所不同.
结论:
- RA 患者患甲状腺功能障碍,特别是甲状腺功能低下的风险增加.
- 血红蛋白和总胆固醇与甲状腺激素和抗体相关,作为甲状腺功能障碍的风险因素.
- 对RA患者来说,对甲状腺功能的临床监测至关重要.
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