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相关概念视频

Taste Buds and Receptors01:20

Taste Buds and Receptors

1.9K
Gustation, or the sense of taste, is intrinsically linked to the anatomical structures located on the tongue. This organ's surface, along with the entirety of the oral cavity, is adorned with stratified squamous epithelium. Evident on the tongue are elevated structures known as papillae (singular = papilla), which house the mechanisms for the transduction of gustatory stimuli. Four distinct types of papillae exist, each identified by their unique morphological attributes: the circumvallate,...
1.9K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

8.9K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
8.9K
The Physiology of Taste01:24

The Physiology of Taste

3.8K
The perception of a salty flavor is facilitated by sodium ions within the oral salivary fluid. Upon consumption of a salty substance, salt crystals disassemble, leading to the liberation of its constituents—Na+ and Cl- ions. These ions subsequently dissolve into the salivary fluid present in the oral cavity. The external environment of the gustatory cells experiences an elevation in Na+ concentration, thereby establishing a potent concentration gradient. This gradient propels the...
3.8K
Gustation01:43

Gustation

47.6K
Gustation is a chemical sense that, along with olfaction (smell), contributes to our perception of taste. It starts with the activation of receptors by chemical compounds (tastants) dissolved in the saliva. The saliva and filiform papillae on the tongue distribute the tastants and increase their exposure to the taste receptors.
47.6K
Conditioned Taste Aversion01:14

Conditioned Taste Aversion

118
Conditioned taste aversion, also known as sauce béarnaise syndrome, is a phenomenon in which an individual develops an aversion to a certain food taste following a negative experience, typically illness. This form of aversion is a type of classical conditioning in which the taste of the food (conditioned stimulus, CS) is associated with the experience of illness (unconditioned stimulus, UCS).
A notable characteristic of conditioned taste aversion is that it often requires only a single...
118
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

65
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
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相关实验视频

Updated: Jun 11, 2025

Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test
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Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test

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老龄化与特定模式的味觉下降有关.

Elizabeth B Brown1,2, Evan Lloyd1,2, Rose Riley1

  • 1Department of Biological Sciences, Florida State University, Tallahassee, FL 32306, USA.

iScience
|October 9, 2024
PubMed
概括

老化会损害果的味道,影响糖的检测,但不会影响脂肪酸的检测. 这种味觉缺陷被粉样β表达模仿,表明明显的衰老和阿尔茨海默氏症.

关键词:
生物科学 生物科学神经科学是一个神经科学.感官神经科学是一种神经科学.

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Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells
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Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells

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Assessment of Midline Lingual Point-Pressure Somatosensation Using Von Frey Hair Monofilaments
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Assessment of Midline Lingual Point-Pressure Somatosensation Using Von Frey Hair Monofilaments

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相关实验视频

Last Updated: Jun 11, 2025

Psychophysical Tracking Method to Assess Taste Detection Thresholds in Children, Adolescents, and Adults: The Taste Detection Threshold TDT Test
08:52

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Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells
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Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells

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Assessment of Midline Lingual Point-Pressure Somatosensation Using Von Frey Hair Monofilaments
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科学领域:

  • 神经科学是一个神经科学.
  • 衰老研究研究 衰老研究
  • 化学感应是一种化学感应.

背景情况:

  • 随着年龄的增长和神经退行性疾病 (如阿尔茨海默氏症) 的发生,化学感官处理会下降.
  • 果,Drosophila melanogaster,作为研究衰老和神经退行的一个模型生物,但其在这些过程中的味觉功能是研究不足的.

研究的目的:

  • 为了研究衰老和神经退行对Drosophila味觉功能的影响.
  • 探索与年龄和AD相关的味觉缺陷背后的具体机制.

主要方法:

  • 行为测试用于评估老年和转基因对糖和脂肪酸的反应.
  • 味觉轴突末端的功能成像.
  • 对味觉神经元中的基因表达的分析.

主要成果:

  • 老化减少了对糖的反应,而不是中链脂肪酸的反应.
  • 人类粉样蛋白β (Aβ) 的表达模仿了与衰老相关的味觉缺陷.
  • 功能性成像显示了轴突终端糖反应的减少,Aβ影响轴突内置.
  • 在糖感应神经元中发现了66种与年龄相关的基因表达变化.

结论:

  • 老年和AD模型的味觉缺陷涉及不同的机制.
  • 衰老主要影响糖分的感知,而粉样β则影响神经元的结构和功能.
  • 草是剖析与年龄和疾病相关的化学感觉障碍的一个有价值的模型.