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Updated: Jun 11, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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Published on: January 16, 2019

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在信号通路内的功能增益和丧失等位基因导致个体之间的表型多样性

Matthew D Vandermeulen1, Sakshi Khaiwal2, Gabriel Rubio1

  • 1Department of Biological Sciences, University at Buffalo, Buffalo, NY 14260-1300, USA.

iScience
|October 9, 2024
PubMed
概括

酵母MAPK信号通路中的遗传变异驱动着表型多样性. 在PAK激酶和G蛋白中的特定突变影响生长和交配,在真核生物中发现了类似的变化,突出了多样性的保存机制.

关键词:
生物化学 生物化学遗传学 是一个遗传学.分子生物学分子生物学

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