相关实验视频
Updated: Jun 11, 2025

10:43
Dissection of Larval Zebrafish Gonadal Tissue
Published on: April 26, 2017
10.2K
人口基因组分析揭示了Apostichopus japonicus的多基因性别确定系统
Chunxi Jiang1,2,3,4, Shilin Liu1,2,3,4, Yujia Yang5
1CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
iScience
|October 9, 2024
概括
海Apostichopus japonicus有一个复杂的多基因性别确定 (PSD) 系统,而不是一个简单的XX/XY机制. 这项研究确定了在这种水产养殖物种中用于分子性别识别的候选基因和标记物.
科学领域:
- 海洋生物学 海洋生物学
- 遗传学 遗传学 是一个
- 水产养殖是水产养殖的一种方式.
背景情况:
- 阿波斯蒂科普斯 (Apostichopus japonicus) 是中国水产养殖的一个重要物种.
- 在A. japonicus中,性别决定机制尚未得到充分理解.
- 了解性别决定对于水产养殖管理和进化研究至关重要.
研究的目的:
- 为了研究Apostichopus japonicus的性别决定的遗传基础.
- 为了确定与性别相关的遗传标记,用于分子性别识别.
- 阐明该物种性别决定的进化意义.
主要方法:
- 在八个野生种群中进行了广泛的性别调查和采样.
- 使用了批量分离分析 (BSA) 和全基因组关联研究 (GWAS).
- 分析了与性别相关的单核酸多态 (SNP) 和插入/删除 (indel) 变异.
主要成果:
- 这些发现表明,在A. japonicus.中存在多基因性决定 (PSD) 系统.
- 溶性载体家族8 (SLC8A),编码-交换器 (NCX1),被确定为候选性别确定基因.
- 染色体6,13,14,16和18的变异支持PSD系统,发现了541.656kb的男性特异序列.
- 五个分子标记物 (C77185,C98086,C64977,C125和C876) 被选用于性别识别.
结论:
- 阿波斯蒂科普斯 (Apostichopus japonicus) 呈现出复杂的,多基因的性别决定机制,挑战了简单的XX/XY系统的概念.
- 已识别的候选基因和标记物为A. japonicus的育种计划和保护工作提供了宝贵的工具.
- 这项研究提供了对皮动物性决定的进化遗传学的关键见解.
相关概念视频
The Ratio of X Chromosome to Autosomes
8.4K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.4K
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Incomplete Dominance
21.8K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
21.8K
The Y Chromosome Determines Maleness
6.5K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
6.5K
Dosage Compensation
6.1K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
6.1K
Epistasis Analysis
4.9K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.9K

