老化肠道微生物群通过氧化应激促进心律失常的易感性
Zhi-Ping Fu1, Yi-Ge Ying1, Rui-Yao Wang1
1Collage of Pharmacology, North China University of Science and Technology, Tangshan 063200, China.
iScience
|October 9, 2024
概括
老龄化改变了肠道微生物群,增加了心律失常的风险. 这项研究表明,老化的肠道微生物通过氧化应激传递心律失常的易感性,影响离子通道.
科学领域:
- 心脏病学 心脏病学
- 微生物学 微生物学
- 老年学是一门学科.
背景情况:
- 心律失常和突然心脏死亡 (SCD) 是重大的健康负担,患病率随着年龄的增长而增加.
- 肠道失调症越来越被认为是导致与年龄有关的疾病,包括心律不整的因素.
研究的目的:
- 研究老化肠道微生物群在促进心律失常的因果作用.
- 阐明关联肠道微生物群,氧化应激和衰老中的心律失常的潜在机制.
主要方法:
- 从老年小鼠移植便微生物群 (FMT) 给年轻小鼠,以评估心律失常的易感性.
- 在老年小鼠中使用抗生素消耗肠道微生物群.
- 研究氧化应激标记物和离子通道蛋白质表达.
- 肠道微生物群代谢物的移植和Vitexin的使用.
主要成果:
- 心律不整的易感性是通过FMT从老年小鼠传染给年轻小鼠的.
- 在老年小鼠中,肠道活性氧物种 (ROS) 的增加与减少的离子通道蛋白表达和心律失常相关.
- 抗生素诱导的肠道微生物群枯竭减少了老年小鼠的ROS和心律失常.
- 老化肠道微生物群在年轻小鼠中诱导了氧化应激,而Vitexin通过OLA1-Nrf2通路减轻了衰老和心律失常.
结论:
- 衰老的肠道微生物群通过诱导全身氧化应激来促进心律失常,从而降低心脏离子通道蛋白表达.
- 针对肠道微生物群和氧化应激通路,为与年龄有关的心律失常提供了潜在的治疗策略.
相关概念视频
01:28Mechanism of Cardiac Arrhythmias
894
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
894
01:28Disturbances in Heart Rhythm
913
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
913
01:16ECG Interpretation of Arrhythmias I: Sinus Arrhythmias
193
Arrhythmias are disturbances in the heart's rhythm that lead to abnormal heartbeats. These irregularities can originate from different parts of the heart and are classified based on their origin and nature.
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
193
01:15Dysrhythmias I: Introduction
4
Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
4
01:17Irritable Bowel Syndrome I: Introduction
254
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
254
01:30Coronary Artery Disease I: Introduction
3
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3